Not quite PIB-positive, not quite PIB-negative: Slight PIB elevations in elderly normal control subjects are biologically relevant

A surface based approach for cortical thickness comparison between PiB+ and PiB- healthy control subjects

~-amyloid has been shown to play a crucial role in Alzheimer' s disease (AD). In vivo ~-amyloid imaging using [11 C) Pittsburgh compound S (PiB) positron emission tomography has made it possible to analyze the relationship between ~-amyloid deposition and different pathological markers involved in AD. PiB allows us to stratify the population between subjects which are likely to have prodromal A...

Clinical Profile of PiB-Positive Corticobasal Syndrome

BACKGROUND Corticobasal syndrome (CBS) is a multifaceted neurodegenerative disorder characterized by a combination of motor and cognitive deficits. Several different pathological entities, including Alzheimer's pathology, have been described in association with CBS. The present study aimed to establish clinical, neuropsychological, and neuroimaging features that could be useful in the distincti...

Nature of motor control: not strictly "motor", not quite "control".

Myocardin--not quite MyoD.

Smooth muscle cells (SMCs) have evolved to subserve a variety of diverse functions in higher vertebrates, including modulation of arterial tone, regulation of airway resistance, and control of gastrointestinal motility. The diverse functional capacities of SMCs are ultimately determined by the expression of genes encoding SMC-restricted contractile and cytoskeletal proteins, intracellular enzym...

Sedation: not quite that simple.

The number of diagnostic and therapeutic interventions performed under sedation is growing rapidly. While providing patients with an improved experience secondary to anxiolysis, analgesia, and amnesia, sedation also puts them at risk for associated cardiorespiratory and other complications. Several medications are available for sedation, all of which have unique advantages and disadvantages. Th...